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While inhibiting TRAb variations may contribute to hypothyroid phenotypes, stimulating TRAb binds to and activates the TSH receptor, resulting in hyperthyroidism and extrathyroidal characteristics such orbitopathy

At the same time, it expands

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Neurodevelopmental disorders Down syndrome Down syndrome (named so after John Langdon Down who described this syndrome under the name of Mongolism in 1866 473 ) is the genetic disorder caused by an extra copy of chromosome 21